Biologically active methylene blue derivatives
AssigneePhotopharmica Limited
InventorsStanley Beames Brown, Cassandra Claire O'Grady, John Griffiths, Kirste Joanne Mellish, Richard George Tunstall, David John Howard Roberts, David Ian Vernon
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Abstract
The present invention relates to a pharmaceutical composition which contains a compound of formula in which R1, R2, R3 and R4 are each n-butyl, where XP− is a counteranion and P is 1, 2 or 3, together with a pharmaceutically acceptable carrier, excipient or adjuvant.
Claims10
A pharmaceutical composition which contains a compound of formula
- in which R1, R2, R3 and R4 are each n-butyl, where XP− is a counteranion and P is 1, 2 or 3, together with a pharmaceutically acceptable carrier, excipient or adjuvant, which composition includes liposomes, nano-particles, colloidal suspensions, micelles, micro-emulsions, vesicles or nano-spheres.
A pharmaceutical composition which contains a compound of formula
- in which R1, R2, R3 and R4 are each n-butyl, where XP− is a counteranion and P is 1, 2 or 3, together with a pharmaceutically acceptable carrier, excipient or adjuvant, which composition includes a delivery vehicle or excipient comprising an isotonising agent selected from the group consisting of urea, glycerol, aminoethanol and propylene glycol.
A pharmaceutical composition which contains a compound of formula
- in which R1, R2, R3 and R4 are each n-butyl, where XP− is a counteranion and P is 1, 2 or 3, together with a pharmaceutically acceptable carrier, excipient or adjuvant, wherein the concentration of said compound is in the range 100 μM to 30 mM.
A pharmaceutical composition which contains a compound of formula
- in which R1, R2, R3 and R4 are each n-butyl, where XP− is a counteranion and P is 1, 2 or 3, together with a pharmaceutically acceptable carrier, excipient or adjuvant, wherein said compound includes Br− as a counterion.
A pharmaceutical composition which contains a compound of formula
- in which R1, R2, R3 and R4 are each n-butyl, where XP− is a counteranion and P is 1, 2 or 3, together with a pharmaceutically acceptable carrier, excipient or adjuvant, which composition also includes a compound of formula
- wherein:
- A and B each independently is
- in which
- R′ and R″ each independently is an optionally substituted linear, branched or cyclic hydrocarbon group, or R′ and R″ together with the N atom to which they are attached form an optionally substituted 5-, 6- or 7-membered ring;
- XP− is a counteranion and P is 1, 2 or 3;
- or one or more other different therapeutic or active agents.
Dependencies are inferred from the claim text.