Use of anti-histaminics for acute reduction of elevated intracranial pressure

A compound according to Formula (I)

• the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof and the N-oxide form thereof, wherein:
• m is 1 or 2;
• n is 0 or 1;
• m+n must equal 2
• a, b, c independently are a single or a double bond;
• X is a covalent bond or a bivalent radical of a C1-6 alkanediyl wherein one or more —CH2—groups may be optionally replaced with —O—, —S—, —CO—, or NR7 — wherein:
• R7 is hydrogen, alkyl, Ar, Ar-alkyl, Het, Het-alkyl, hydroxyalkyl, alkyloxy, alkyloxyalkyl, alkyloxyalkyloxyalkyl, aminoalkyl, mono- or dialkylaminoalkyl, formyl, alkylcarbonylaminoalkyl, alkylcarbonyloxyalkyl, alkyloxycarbonyl, alkyloxycarbonylalkyl, alkylaminocarbonyl, alkylaminocarbonylalkyl, hydroxyalkyloxyalkyl, aminocarbonyl, aminocarbonylalkyl, alkyloxycarbonyl or alkylcarbonyloxyalkyloxyalkyl;
• Y is —CH2—CH2—,
• Z is N, in which case a is a double bond and b is a single bond or N—R7 in which case a is a single bond, b is a double bond and R7 is defined as above;
• R1, R2 independently are hydrogen, hydroxy, alkyl, alkyloxy, Ar, Ar-alkyl, di(Ar-)alkyl, Het or Het-alkyl;
• —A—B- independently is a bivalent radical of formula
• —E—CR8═CR8— (a-1);
• —CR8═CR8—E— (a-2);
• —CR8═CR8—CR8═CR8— (a-3);
• wherein
• R8 each independently is hydrogen, halo, hydroxy, alkyl or alkyloxy;
• E is a bivalent radical of formula —O—, —S—or—NR7- wherein R7 is defined as above;
• —C—D— independently is a bivalent radical of formula
• —CR8═CR8—CR8═CR8— (b-1);
• —N═CR8—CR8═CR8— (b-2);
• —CR8═N—CR8═CR8— (b-3);
• —CR8═CR8—N═CR8— (b-4);
• —CR8═CR8—CR8═N— (b-5);
• wherein R8 is defined as above;
• R3 is hydrogen, halo, hydroxy, alkyl, alkyloxy, Ar, Ar-alkyl, di(Ar-)alkyl, Het or Het-alkyl;
• R4 is hydrogen, alkyl, amino, alkylamino, Ar-amino, Het-amino, alkylcarbonylamino, Ar-carbonylamino, Het-carbonylamino, alkylaminocarbonylamino, Ar-aminocarbonylamino, Het-aminocarbonylamino, alkyloxyalkylamino, Ar-oxyalkylamino or Het-oxyalkylamino;
• R5 is hydrogen or alkyl;
• or R4 and R5 together may form a bivalent radical of Formula
• —M—CR9═CR10— (c-1);
• —CR10═CR9—M— (c-2);
• —M—CR9R8—CR10R8— (c3);
• —CR10R8—CR9R8—M— (c-4);
• —CR8═N—NR7— (c-5);
• —NR7—N═CR8— (c-6);
• —CR8═CR9—CR10═CR8— (c-7);
• —CR8R8—CR9R8—CR10R8—M— (c-8);
• —M—CR10R8—CR9R8—CR8R8— (c-9);
• —CR8R8—CR8═N—NR7— (c-10);
• —NR7—N═CR8—CR8R8— (c-11);
• wherein
• R7 and R8 are defined as above;
• R9, R10 independently are hydrogen, alkyl, halo, haloalkyl;
• or R9 and R10 together may form a bivalent radical of formula —CR8═CR8—CR8═CR8—;
• and
• M is a bivalent radical of formula —CH2—,—O—, —S— or —NR7— wherein R7 is defined as above;
• Ar is a homocycle selected from the group of naphthyl and phenyl, each optionally substituted with 1, 2 or 3 substituents, each substituent independently selected from the group of hydroxy, halo, cyano, nitro, amino, mono- or dialkylamino, alkyl, haloalkyl, alkyloxy, haloalkyloxy, carboxyl, alkyloxycarbonyl, aminocarbonyl and mono- or dialkylaminocarbonyl;
• Het is a monocyclic heterocycle selected from the group of pyrrolyl, pyrazolyl, imidazolyl, furanyl, thienyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, pyridinyl, pyrimidinyl, pyrazinyl and pyridazinyl;
• or a bicyclic heterocycle selected from the group of quinolinyl, quinoxalinyl, indolyl, benzimidazolyl, benzoxazolyl, benzisoxazolyl, benzothiazolyl, benzisothiazolyl, benzofuranyl and benzothienyl ;
• each monocyclic and bicyclic heterocycle may optionally be substituted on a carbon atom with halo, hydroxy, alkyl or alkyloxy;
• alkyl is a straight or branched saturated hydrocarbon radical having from 1 to 6 carbon atoms;
• or is a cyclic saturated hydrocarbon radical having from 3 to 6 carbon atoms;
• or is a a cyclic saturated hydrocarbon radical having from 3 to 6 carbon atoms attached to a straight or branched saturated hydrocarbon radical having from 1 to 6 carbon atoms;
• wherein each carbon atom can be optionally substituted with halo, hydroxy, alkyloxy or oxo;
• halo is a substituent selected from the group of fluoro, chloro, bromo and iodo;
• haloalkyl is a straight or branched saturated hydrocarbon radical having from 1 to 6 carbon atoms or a cyclic saturated hydrocarbon radical having from 3 to 6 carbon atoms, wherein one or more of any member of either group of said carbon atoms are substituted with one or more halo-atoms.