Surgical compositions and methods of using the same
AssigneeInnovata Limited
InventorColin Brown
Life of this patent
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Abstract
A method of preventing or reducing the incidence of post-operative adhesions in or associated with a body cavity, which comprises introducing into the body cavity a composition containing an aqueous solution or suspension or gel formulation containing the polysaccharide dextrin.
Claims50
A method of treating a patient to reduce, in a post-operative period following surgery involving a body cavity, the incidence of post-operative adhesions in the body cavity, comprising treating said patient prior to said post-operative period by introducing into the body cavity an an aqueous formulation comprising a polysaccharide dextrin in an amount effective to reduce the incidence of said post-operative adhesions, wherein the dextrin is unsubstituted and the dextrin contains more than 15% of polymers with a degree of polymerization (DP) greater than 12 and acts as an osmotic agent to maintain a volume of the aqueous formulation in the body cavity serving to separate tissues which otherwise may adhere to each other, and wherein the aqueous formulation is a solution in the body cavity and further remains in the body cavity for at least 2 days, wherein the aqueous formulation that is introduced prior to said post-operative period provides said treating.
A method of treating a patient to reduce, in a post-operative period following surgery involving a body cavity, the incidence of post-operative adhesions in the body cavity, comprising treating said patient prior to said post-operative period by introducing into the body cavity an aqueous formulation comprising a polysaccharide dextrin in an amount effective to reduce the incidence of said post-operative adhesions, wherein the dextrin is unsubstituted and the dextrin contains more than 15% of polymers with a degree of polymerization (DP) greater than 12 and acts as an osmotic agent to maintain a volume of the aqueous formulation in the body cavity serving to separate tissues which otherwise may adhere to each other, wherein the aqueous formulation that is introduced prior to said post-operative period provides said treating and wherein:
- (a) the aqueous formulation is a solution in the body cavity, remains in the body cavity for at least 2 days and is not removed;
- (b) the dextrin is applied to the body cavity in an amount of about 4% weight to volume of the aqueous formulation;
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- (c) the aqueous formulation is administered intraperitoneally.
A method of treating a patient to reduce, in a post-operative period following surgery involving body cavity, the incidence of post-operative adhesions in the body cavity, comprising:
- (a) treating said patient prior to said post-operative period by introducing into the body cavity an aqueous formulation comprising a polysaccharide dextrin in an amount effective to reduce the incidence of said post-operative adhesions, wherein the dextrin is unsubstituted and the dextrin contains more than 15% of polymers with a degree of polymerization (DP) greater than 12 and acts as an osmotic agent to maintain a volume of the aqueous formulation in the body cavity serving to separate tissues which otherwise may adhere to each other, and wherein the aqueous formulation is a solution in the body cavity;
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- (b) allowing the aqueous formulation to remain in the body cavity for at least 2 days, wherein the aqueous formulation is not removed from the body cavity, wherein the aqueous formulation that is introduced prior to said post-operative period provides said treating.
A method of treating a patient to reduce, in a post-operative period following surgery involving a body cavity, the incidence of post-operative adhesions in the body cavity, comprising treating said patient prior to said post-operative period by introducing into the body cavity an aqueous formulation comprising a polysaccharide dextrin in an amount effective to reduce the incidence of said post-operative adhesions, wherein the dextrin is unsubstituted and the dextrin contains more than 15% of polymers with a degree of polymerization (DP) greater than 12 and acts as an osmotic agent to maintain a volume of the aqueous formulation in the body cavity serving to separate tissues which otherwise may adhere to each other, and wherein the aqueous formulation is a solution in the body cavity administered under surgical conditions and the aqueous formulation remains in the body cavity and is not removed, wherein the aqueous formulation that is introduced prior to said post-operative period provides said treating.
A method of treating a patient to reduce, in a post-operative period following, surgery involving a body cavity, the incidence of post-operative adhesions in the body cavity, comprising treating said patient prior to said post-operative period by introducing into the body cavity a composition comprising less than 2000 ml of an aqueous formulation containing a polysaccharide dextrin in an amount effective to reduce the incidence of said post-operative adhesions, wherein the dextrin is unsubstituted and the dextrin contains more than 15% of polymers with a degree of polymerization (DP) greater than 12 and acts as an osmotic agent to maintain a volume of the aqueous formulation in the body cavity serving to separate tissues which otherwise may adhere to each other, and wherein the aqueous formulation is a solution in the body cavity and the aqueous formulation remains in the body cavity and is not removed, wherein the aqueous formulation that is introduced prior to said post-operative period provides said treating.
Dependencies are inferred from the claim text.