Loading patent…
AssigneeUniversity of Delaware
InventorsKristi L. Kiick, Nori Yamaguchi, John Rabolt, Cheryl Casper
Estimating the term…
The present invention relates to a biologically active functionalized electrospun matrix to permit immobilization and long-term delivery of biologically active agents. In particular the invention relates to a functionalized polymer matrix comprising a matrix polymer, a compatibilizing polymer and a biomolecule or other small functioning molecule. In certain aspects the electrospun polymer fibers comprise at least one biologically active molecule functionalized with low molecular weight heparin. Examples of active molecules that may be used with the multicomponent polymer of the invention include, for example, a drug, a biopolymer, for example a growth factor, a protein, a peptide, a nucleotide, a polysaccharide, a biological macromolecule or the like. The invention is further directed to the formation of functionalized crosslinked matrices, such as hydrogels, that include at least one functionalized compatibilizing polymer capable of assembly.
A functionalized polymer matrix comprising a matrix polymer, a compatibilizing polymer, wherein the compatibilizing polymer comprises PEG, and a small molecule, wherein the small molecule comprises LMWH or heparin-binding peptide and is covalently attached to the compatibilizing polymer, wherein the polymer matrix comprises between about 0.35% wt/wt and about 0.95% wt/wt compatibilizing polymer and is capable of forming a drug delivery device for the in situ delivery of therapeutic compounds.
A functionalized polymer matrix comprising a matrix polymer, a compatibilizing polymer and a small molecule, wherein the small molecule comprises LMWH or heparin-binding peptide and is covalently attached to the compatibilizing polymer, wherein the polymer matrix comprises between about 0.35% wt/wt and about 8.5% wt/wt compatibilizing polymer and is capable of forming a drug delivery device for the in situ delivery of therapeutic compounds, and wherein the compatibilizing polymer comprises a four-arm star PEG.
Dependencies are inferred from the claim text.