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US 7,732,425 B2Granted
Pharmaceutical composition for ophthalmic use
AssigneeKabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo
InventorsToshihiko Matsuo, Masashi Kurimoto, Hiroshi Yamauchi
Life of this patent
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Abstract
An ophthalmic pharmaceutical composition comprising trehalose as an effective ingredient and a pharmaceutically-acceptable carrier. The pharmaceutical composition is a safe, long-term continuously-administrable, therapeutic and/or prophylactic agent for the ophthalmologic clinical symptoms and signs in Sjögren syndrome.
Claims3
A method for treeing a patient suffering from dry eye, comprising:
- a. introducing a liquid ophthalmic pharmaceutical composition into a container for close application to the face-line around the patient's eye(s), said liquid ophthalmic pharmaceutical composition being in the form of an eyewash free of benzalkonium chloride, having a pH of 6.5 to 7.5 and an osmotic pressure of 0.5 to 4.0, and comprising (i) trehalose as an effective ingredient, (ii) one or more oligosaccharides consisting of more than three glucose molecules in an amount of 0.001 to 2 times of said trehalose, and (iii) an ophthalmologically-acceptable carrier;
- b. applying said container to the face-line of said patient to deliver said liquid ophthalmic pharmaceutical composition to the patient's eye(s);
- and
- c. allowing the patient to blink several times whereby the patient's eye(s) contacts the liquid ophthalmic pharmaceutical composition,
- whereby the symptoms of dry eye of said patient are improved or remitted.
2 more elements
Dependencies are inferred from the claim text.