US 7,732,424 B2 · Purine derivatives and methods of use thereof

Abstract

The present invention relates to Purine Derivatives; compositions comprising an effective amount of a Purine Derivative; and methods for reducing an animal's core body temperature, protecting an animal's heart against myocardial damage during cardioplegia; or for treating or preventing a cardiovascular disease, a neurological disorder, an ophthalmic condition, an ischemic condition, a reperfusion injury, obesity, a wasting disease, or diabetes, comprising administering an effective amount of a Purine Derivative to an animal in need thereof. The Purine Derivatives include compounds of the following formula: or a pharmaceutically acceptable salt thereof wherein A is —CH2OH B and C are —OH: D is A and B are trans with respect to each other: B and C are cis with respect to each other: C and D are cis or trans with respect to each other: R1 is —H, -halo, —CN, —N(R2)2, —OR2, —SR2, —NHC(O)R2, —NHC(O)N(R2)2, —NHC(O)OR2, —C(O)OR2, —C(O)R2, —C(O)N(R2)2, —OC(O)N(R2)2, —C(halo)3, or —NO2; each R2 is independently —H, —C1-C10 alkyl, —C2-C6 alkenyl, —C2-C6 alkynyl, —(CH2)n-aryl, —(CH2)n-(3- to 7-membered monocyclic heterocycle, —(CH2)n-(8- to 12-membered bicyclic heterocycle), —(CH2)n—(C3-C8 monocyclic cycloalkyl), —(CH2)n—(C3-C8 monocyclic cycloalkenyl), —(CH2)n—(C8-C12 bicyclic cycloalkyl), or —(CH2)n—(C8-C12 bicyclic cycloalkenyl); each n is an integer ranging from 0 to 6; each p is an integer ranging from 1 to 6; and each q is an integer ranging from 1 to 6.

Claims35

Dependent claims

A compound having the formula

or a pharmaceutically acceptable salt thereof,
wherein
A is —CH2OH;
B and C are OH;
D is
A and B are trans with respect to each other;
B and C are cis with respect to each other;
C and D are cis or trans with respect to each other;
R1 is —H, or -halo;
each p is an integer ranging from 1 to 6;
and
each q is an integer ranging from 1 to 6.

9 more elements

Dependencies are inferred from the claim text.

Purine derivatives and methods of use thereof

Life of this patent

Purine derivatives and methods of use thereof

Life of this patent

Abstract

Claims35