Nucleotide vector, composition containing such vector, and vaccine for immunization against hepatitis
AssigneesInstitut Pasteur, Institut National de la Sante et de la Recherche Medicale
InventorsMarie-Louise Michel, Maryline Mancini
Life of this patent
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Abstract
Nucleotide composition containing a vector and vaccine for immunization against hepatitis. Nucleotide vector comprising at least one gene or one complementary DNA coding for at least a portion of a virus, and a promoter providing for the expression of the gene in muscle cells. The gene may be the S gene of the hepatitis B virus. A nucleotide vector composition when administered to even chronic HBV carriers is capable of breaking T cell tolerance to the surface antigens of hepatitis B virus. A vaccine preparation containing bare DNA is injected into the host previously treated with a substance capable of inducing a coagulating necrosis of the muscle fibers.
Claims18
A method for breaking T-cell tolerance in a chronic HBV carrier comprising administering to the chronic HBV carrier a vector,
- wherein the vector comprises a gene or a DNA encoding an antigenic portion of HBV S, preS2-S, or preS1-preS2-S proteins of HBV operably linked to a promoter, and
- wherein the vector is administered to the chronic HBV carrier in an amount sufficient to break T-cell tolerance.
Dependencies are inferred from the claim text.