EspFU nucleic acids and proteins and uses thereof
AssigneeUniversity of Massachusetts
InventorsJohn M. Leong, Kenneth G. Campellone
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Abstract
Disclosed are EspFU (EspF-like polypeptide encoded by a gene of the cryptic prophage CP-933U of enterohemorrhagic E. coli) polypeptides, fragments thereof, nucleic acids that encode EspFU polypeptides, or fragments thereof, and cells including the polypeptides, fragments, and/or nucleic acids. Also disclosed are model systems, kits, and methods for screening that use, for example, EspFU polypeptides and nucleic acids. Also included are pharmaceutical and diagnostic compositions and methods of diagnosis and treatment of EHEC infections.
Claims15
A purified polypeptide that comprises an amino acid sequence that is at least 97% identical to SEQ ID NO:2, wherein said polypeptide binds to a neuronal Wiskott-Aldrich syndrome protein (N-WASP).
A purified polypeptide encoded by a nucleic acid at least 98% identical to nucleotides 238-1152 of SEQ ID NO:1.
A purified polypeptide that comprises an amino acid sequence that is at least 95% identical to amino acids 80 to 384 of SEQ ID NO:2 (SEQ ID NO:4), wherein said polypeptide binds to a neuronal Wiskott-Aldrich syndrome protein (N-WASP).
Dependencies are inferred from the claim text.