Back to results
US 7,732,404 B2Granted
Pro-nanodispersion for the delivery of cyclosporin
AssigneeDexcel Ltd.
InventorsAbraham J. Domb, Avi Avramoff, Victor Pevzner
Life of this patent
Estimating the term…
Abstract
A novel cyclosporine formulation, which is a pro-nanodispersion at room temperature, featuring solid particles of a relatively large particle size (at least about 150 nm) and yet which is a nanodispersion at body temperature.
Claims13
A composition for administering a cyclosporin compound, the composition comprising:
- (a) a pro-nanodispersion comprising:
- (i) a solid fat;
- (ii) ethyl lactate;
- (iii) at least two surfactants comprising a low HLB surfactant and a high HLB surfactant, wherein a difference between the HLB values for said low and said high HLB surfactants is at least about 5 units;
- and (iv) an ethoxylated fat;
- (b) a pharmaceutically effective amount of the cyclosporin compound;
- and a suitable diluent for administration to the eye.
4 more elements
Dependencies are inferred from the claim text.