Inhibitor of TGF-β activation reaction
AssigneeRiken
InventorsSouichi Kojima, Ryutaro Teraoka
Life of this patent
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Abstract
The present invention aims to provide a substance(s), especially a peptide(s) capable of inhibiting the TGF-β activation reaction. The present invention provides a peptide consisting of 11 to 50 amino acid residues, which comprises an amino acid sequence Gln-Ile-Leu-Ser-X1-X2-X3-X4-Ala-Ser-Pro (SEQ ID NO: 1) wherein each of X1 to X4 independently represents any given amino acid residue, and X1-X2-X3-X4 is a sequence that is not Lys-Leu-Arg-Leu (SEQ ID NO: 12) and is not cleavable by proteases.
Claims7
A peptide consisting of 11 to 50 amino acid residues, which comprises an amino acid sequence, Gln-Ile-Leu-Ser-X1-X2-X3-X4-Ala-Ser-Pro (SEQ ID NO:
- 1) wherein each of X1 to X4 independently represents any amino acid residue, and X1-X2-X3-X4 is a sequence that is not Lys-Leu-Arg-Leu (SEQ ID NO:
- 12) and is not cleavable by plasmin and/or plasma kallikrein.
A peptide consisting of 11 to 50 amino acid residues, which comprises the amino acid sequence of any one of the following (1) to (4):
- (SEQ ID NO:
- 2)
- Gln-Ile-Leu-Ser-Ala-Ala-Ala-Ala-Ala-Ser-Pro (1);
- (SEQ ID NO:
- 3)
- Gln-Ile-Leu-Ser-Ala-Leu-Ala-Leu-Ala-Ser-Pro (2);
- (SEQ ID NO:
- 4)
- Gln-Ile-Leu-Ser-Gln-Gln-Gln-Gln-Ala-Ser-Pro (3);
- and
- (SEQ ID NO:
- 5)
- Gln-Ile-Leu-Ser-Gln-Leu-Gln-Leu-Ala-Ser-Pro (4).
Dependencies are inferred from the claim text.