Medicinal uses of mu-opioid receptor agonists
AssigneesCornell Research Foundation, Inc., Clinical Research Institute of Montreal
InventorsHazel Szeto, Peter W. Schiller
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Abstract
The present invention provides methods for stimulating mu-opioid receptors with agonist peptides in a mammal in need thereof. The methods comprise administering to the mammal an effective amount of a selective mu-opioid receptor agonist peptide that comprises at least two α-amino acid residues. At least one of the amino acid residues has a positive charge. The amino acid residue in the first position is a tyrosine or tyrosine derivative. The amino acid in the second position is a D-α-amino acid. The present invention also provides methods of treating a mammal suffering from conditions or diseases by administering to the mammal an effective amount of the peptides.
Claims11
A method for inhibiting norepinephrine uptake in a mammal in need of analgesia, the method comprising administering to the mammal an effective amount of a selective mu-opioid receptor agonist peptide selected from the group consisting of:
- 2′,6′-dimethyl-Tyr-D-Arg-Phe-Lys-NH2 ((Dmt1)DALDA);
- 2′,6′-dimethyl-Tyr-D-Ala-Phe-Phe-NH2 ((Dmt1)TAPP);
- and
- 2′,6′-dimethyl-Tyr-D-Arg-Phe-Orn-NH2,
- wherein said effective amount is effective to reduce or inhibit norephinephrine uptake in the mammal.
Dependencies are inferred from the claim text.