Use of cardiotrophin in liver diseases
AssigneeProyecto De Biomedicina Cima, S.L.
InventorsMatilde Bustos De Abajo, Jesús Prieto Valtueña, Juan José Lasarte Sagastibelza, Elena Baixeras Llano
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Abstract
Use of cardiotrophin in liver diseases. The invention describes the increased expression of cardiotrophin (CT-1) during the process of hepatic regeneration coinciding with maximum proliferation of hepatocytes and the role of CT-1 as a stimulator of hepatic regeneration. Furthermore, it describes the hepatoprotective role of CT-1 in various models of acute liver damage. The importance of using CT-1 in the manufacture of compositions for use in the treatment of hepatopathies is demonstrated. The invention describes such use in various forms and methods, including the recombinant protein and the use of the gene sequences that code for CT-1.
Claims16
A method for treating a subject whose liver has experienced a loss of functional liver cells, the method comprising administering to the subject cardiotrophin-1 (CT-1) in an amount effective for exerting an antiapoptotic effect in hepatocytes of the subject and for stimulating DNA synthesis in hepatocytes of the subject or for proliferation or differentation of hepatocytes in the subject.
A method for preventing damage to a liver in a subject in need of or subject to a hepatectomy or liver transplant comprising administration to the subject prior to the hepatectomy or transplant of an amount of cardiotrophin-1 (CT-1) effective to exert an antiapoptotic effect in hepatocytes of the subject.
Dependencies are inferred from the claim text.