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US 7,732,214 B2Granted
Differentiation of acute and chronic myocardial necrosis in symptomatic patients
AssigneeRoche Diagnostics Operations, Inc.
InventorsGeorg Hess, Andrea Horsch
Life of this patent
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Abstract
The present invention provides methods for diagnosing an acute cardiovascular event and for differentiating between an acute cardiovascular event and chronic heart failure based on measuring a cardiac troponin and a natriuretic peptide in a sample from a patient and comparing the measured amounts with reference amounts, as well as devices and kits for carrying out such methods.
Claims12
A method for differentiating between an acute cardiovascular event and chronic heart failure comprising the steps of:
- a. determining an amount of a cardiac troponin in a sample from a human subject,
- b. determining an amount of a natriuretic peptide in a sample from said subject, and
- c. differentiating between an acute cardiovascular event and chronic heart failure by comparing the amounts determined in steps a) and b) with reference amounts,
- wherein a reference amount for the cardiac troponin between and including 0.01 ng/ml and 3.5 ng/ml and a reference amount for the natriuretic peptide of at least 500 pg/ml are indicative for chronic heart failure, and
- wherein a reference amount for the cardiac troponin of greater than 0.01 ng/ml and a reference amount for the natriuretic peptide of less than 500 pg/ml are indicative for an acute cardiovascular event or wherein a reference amount for the cardiac trononin of at least 3.5 ng/ml and a reference amount of the natriuretic peptide of at least 500 pg/ml are indicative for an acute cardiovascular event.
2 more elements
A method for diagnosing an acute cardiovascular event comprising the steps of:
- a. determining an amount of a cardiac troponin in a sample from a human subject,
- b. determining an amount of a natriuretic peptide in a sample from said subject, and
- c. diagnosing an acute cardiovascular event by comparing the amounts determined in steps a) and b) with reference amounts,
- wherein a reference amount for the cardiac troponin of at least 0.01 ng/ml and a reference amount for the natriuretic peptide of less than 500 pg/ml are indicative for an acute cardiovascular event or wherein a reference amount for the cardiac troponin of at least 3.5 ng/ml and a reference amount of the natriuretic peptide of at least 500 pg/ml are indicative for an acute cardiovascular event.
1 more element
Dependencies are inferred from the claim text.