Oligodendrocyte determination genes and uses thereof
AssigneeCalifornia Institute of Technology
InventorsDavid J. Anderson, Qiao Zhou
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Abstract
The invention relates to methods and reagents for promoting the differentiation of oligodendrocytes from stem cells, by co-activating the Olig genes and the Nkx2.2 genes, and the use of the differentiated oligodendrocytes thus obtained in treating diseases, such as Multiple Sclerosis (MS). The invention also relates to the use of OLPs and oligodendrocytes thus obtained for drug screening.
Claims9
A method to promote in vitro differentiation of a neural stem cell, a neural progenitor cell, or an embryonic stem cell from a mammal to an oligodendrocyte precursor (OLP) or an oligodendrocyte (ODC), comprising co-expressing in said neural stem cell, neural progenitor cell, or embryonic stem cell an exogenous Olig gene and an exogenous Nkx2.2 gene.
Dependencies are inferred from the claim text.