Method for transdifferentiating mesenchymal stem cells into neuronal cells
AssigneeAjoll University Industry Cooperation Foundation
InventorsHae-Young Suh, Sung-Soo Kim, Ji-Won Kim, Young-Don Lee, Seung-Cheol Ahn
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Abstract
This inventive discloses a method for transdifferentiating mesenchymal stem cells into neuronal cells, which comprises increasing the level of a basic helix-loop-helix (bHLH) transcription factor in the mesenchymal stem cells, said cells being useful in cell therapy or gene therapy for treating brain neurological diseases such as Parkinson's disease, Alzheimer disease, Hungtington's disease, amyotrophic lateral sclerosis, cerebral paralysis and brain ischemia; and spine disfunction caused by a traumatic injury.
Claims5
An in vitro method for transdifferentiating mesenchymal stem cells into neuronal cells, which comprises increasing the level of a basic helix-loop-helix (bHLH) transcription factor in the mesenchymal stem cells by transducing a nucleic acid sequence encoding the bHLH transcription factor and adding 5-aza deoxycitidin and then forskolin, to the mesenchymal stem cells.
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