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US 7,732,201 B2Granted
Method for production of neuroblasts
AssigneeThe Regents of the University of California
InventorsFred H. Gage, Jasodhara Ray
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Abstract
A method for producing a neuroblast and a cellular composition comprising an enriched population of neuroblast cells is provided. Also disclosed are methods for identifying compositions which affect neuroblasts and for treating a subject with a neuronal disorder, and a culture system for the production and maintenance of neuroblasts.
Claims16
A composition comprising:
- a population of isolated neural cells comprising a neuroblast and a nestin-positive neural cell, wherein the isolated neural cells are derived from the CNS of an adult mammal, and
- a culture medium comprising about 1 ng/ml to 100 ng/ml of basic fibroblast growth factor (bFGF);
- wherein the population has been continuously proliferating in vitro greater than 21 days, and wherein the composition is free of epidermal growth factor (EGF).
Dependencies are inferred from the claim text.