Protozoan strains of reduced virulence and use thereof
AssigneesInstitut De Recherche Pour Le Developpement, Universidade Do Porto
InventorsAnabela Cordeira Da Silva, Ali Ouaissi, Denis Sereno, Baptiste Vergnes
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Abstract
The present invention relates to a protozoan strain of the family of the Trypanosomatidae the virulence of which is lower than that of the corresponding wild-type strain, characterized in that at least one copy of the SIR2 gene present in the genome of the strain is inactivated.
Claims2
A protozoan strain of the species Leishmania infantum the virulence of which is lower than that of the corresponding wild-type strain, wherein one copy of the SIR2 gene present in the genome of said strain is inactivated by insertion of the NEO gene in the sequence represented by SEQ ID NO:
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Dependencies are inferred from the claim text.