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US 7,732,171 B2Granted
Process for the preparation of dihydroxy esters and derivatives thereof
AssigneeAstraZeneca UK Limited
InventorsAndrew John Blacker, Christopher David Reeve, Robert Antony Holt
Life of this patent
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Abstract
A process is provided for the preparation of a compound of formula (1) wherein R and R′ represent optionally substituted hydrocarbyl groups and X represents a hydrocarbyl linking group. The process comprises either the stereoselective reduction of the keto group in a dihydroxy keto precursor followed by selective esterification of a primary hydroxy, or selective esterification of a primary hydroxy of a dihydroxy keto precursor followed by stereoselective reduction of the keto group.
Claims7
A process for the preparation of a compound of formula (1)
- which comprises esterification of a compound of formula (3)
- in the presence of a compound of formula R″-O—COR′ and a lipase or hydrolase enzyme thereby to form the compound of formula (1);
- wherein
- X represents an optionally substituted hydrocarbyl linking group;
- R and R″ each independently represent an optionally substituted hydrocarbyl group;
- and
- R′ represents an optionally substituted hydrocarbyl.
4 more elements
Dependencies are inferred from the claim text.