Extracellular serine protease
AssigneeBoard of Trustees of the University of Arkansas
InventorsTimothy J. O'Brien, Lowell J. Underwood, John Beard, Kazushi Shigemasa
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Abstract
The present invention provides a DNA encoding a novel extracellular serine protease termed Tumor Antigen Derived Gene-14 (TADG-14) which is overexpressed in ovarian, breast and colon carcinoma samples. Also provided are vector and host cells capable of expressing the DNA of the present invention, as well as the uses of the DNA and protein of the present invention. Also provided is a TADG-14 protein variant that has a potential role for detecting and targeting of ovarian carcinomas.
Claims4
An isolated DNA that differs from the nucleic acid sequence of SEQ ID NO:
- 6 due to inclusion of an intron sequence between exon 2 and exon 3 of SEQ ID NO:
- 6, said DNA encoding a TADG-14 protein variant with an amino acid sequence shown in SEQ ID NO:
- 75.
Dependencies are inferred from the claim text.