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US 7,732,135 B2Granted
Genetic markers of food allergy
OwnerGurjit K. Khurana Hershey, Amal Assa'ad +1inventors
InventorsGurjit K. Khurana Hershey, Amal Assa'ad, Ranajit Chakraborty
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Abstract
A genetic marker of food allergy is disclosed. The marker comprises variants of IL-4 receptor alpha, IL13 and CD14.
Claims5
A method of determining an individual's propensity to a peanut allergy, the method comprising
- screening nucleic acid of the individual for the presence of a combination of markers which results in QR at position 130 of the polypeptide of IL-13, VV at position 75 of the IL-4Rα polypeptide, and TT at position -159 of the CD 14 promoter, and
- identifying the individual as having an increased propensity to a peanut allergy if the combination of markers is present.
A method of determining an individual's propensity to a milk allergy comprising
- screening nucleic acid of the individual for the presence of a combination of markers which results in VV at position 75 of the IL-4Rα polypeptide and TT at position -159 of the CD 14 promoter, and
- identifying the individual as having an increased propensity to a milk allergy if the combination of markers is present.
A method to determine an individual's propensity to a food allergy, the method comprising
- determining the presence of an allele combination comprising a genotype which results in V at polypeptide position 75 of IL-4Rα, Q at polypeptide position 130 of IL-13, and T at nucleotide position -159 of CD14 promoter in at least one cell in the individual, wherein the presence of the allele combination indicates the individual's increased propensity to a food allergy.
Dependencies are inferred from the claim text.