Powdery composition for nasal administration

A powdery composition for nasal administration comprising

• (i) a drug,
• (ii) one or more of a water-absorbing and gel-forming base material selected from the group consisting of hydroxypropyl cellulose, hydroxypropylmethyl cellulose, methyl cellulose, hydroxyethyl cellulose, and sodium carboxymethyl cellulose and
• (iii) one or more of a water-absorbing and water-insoluble base material selected from the group consisting of crystalline cellulose, α-cellulose, cross-linked sodium carboxy-methyl cellulose, cross-linked starch, chitin and chitosan,
• wherein the content of the water-absorbing and gel-forming base material is about 5-40 wt % based on the total of the water-absorbing and water-insoluble base material and the water-absorbing and gel-forming base material,
• 70 wt % or more based on the drug is dispersed on or in the water-absorbing and water-insoluble base material and on or in the water-absorbing and gel-forming base material,
• the water-absorbing and water-insoluble base material and water-absorbing and gel-forming base material comprise particles,
• wherein the drug is dispersed more on or in the water-absorbing and water-insoluble base material than in a state in which the drug is adhered to the both base materials according to their compounding ratio, and
• wherein the powdery composition is obtained by a method comprising dissolving or dispersing the drug and the water-absorbing and water-insoluble base material in an organic solvent to obtain a resultant solution or dispersion, and
• subsequently evaporating the resultant solution or dispersion to obtain a powder, further pulverizing and sieving the powder to obtain a resultant powder comprising water-absorbing and water-insoluble particles, wherein at least 90 wt % based on the water absorbing and water-insoluble particles have an average particle diameter in the range of 10-350 pm, and
• mechanically mixing the water-absorbing and gel-forming base material, in which at least 90 wt % based on the water-absorbing and gel-forming particles have an average particle diameter in the range of 10-350 μm, with the resultant powder.