Implantable medical device comprising a pro-healing poly(ester-amide)

An implantable medical device, comprising:

• a device body and at least one layer comprising a poly(ester-amide) having the formula:
• an optional primer layer disposed over the device body;
• a drug reservoir layer disposed over the device body or the primer layer, if opted, wherein the drug reservoir layer comprises one or more therapeutic agents;
• an optional rate-controlling layer disposed over at least a portion of the drug reservoir layer, if opted;
• and,
• an optional top-coat layer disposed as an outermost layer over the device body, the primer layer, if opted, the drug reservoir layer, if opted, or the rate-limiting layer, if opted,
• wherein:
• m is an integer from 0 to about 200;
• p is an integer from 0 to about 200;
• n is an integer from 1 to about 200;
• r is an integer from 1 to about 3000;
• Mw is from about 10,000 Da to about 1,000,000 Da;
• s is a number from 0 to 1, inclusive;
• t is a number from 0 to 1, inclusive;
• v is a number from 0 to 1, inclusive;
• wherein:
• s+t+v=1;
• X has the chemical structure:
• Y has the chemical structure:
• Z has the chemical structure:
• wherein:
• R1, R1′ and R4 are independently selected from the group consisting of (1C-12C)alkyl and (2C-12C)alkenyl;
• R2, R2′, R2″ and R2′″ are independently selected from the group consisting of hydrogen and (1C-4C)alkyl, wherein:
• the alkyl group is optionally substituted with a moiety selected from the group consisting of —OH, —O(1C-4C)alkyl, —SH, —S(1C-4C)alkyl, —SeH, —COR6, —NHC(NH)NH2, imidazol-2-yl, imidazole-5-yl,
• indol-3-yl, phenyl, 4-hydroxyphenyl and 4-[(1C-4C)alkylO]phenyl, wherein:
• R6 is selected from the group consisting of —OH, —O(1C-4C)alkyl, —NH2, —NH(1C-4C)alkyl, —N(1C-4C)alkyl1(1C-4C)alkyl2, a stable nitroxide, —O(CH2)2OP(═O)(O−)OCH2CH2N30 (CH3)3, —O(CH2CH2O)qCH2CH2OR7 and
• where:
• the stable nitroxide is selected from the group consisting of
• R7 is selected from the group consisting of hydrogen, (1C-4C)alkyl, —C(O)CH═CH2, —C(O)C(CH3)═CH2 and —O(CH2)2OP(═O)(O−)OCH2CH2N+(CH3)3;
• or
• one or more of R2, R2′, R2″ and R2′″ may form a bridge between the carbon to which it is attached and the adjacent nitrogen, the bridge comprising
• —CH2CH2CH2—;
• R3 is selected from the group consisting of (1C-12C)alkyl and(2C-12C)alkenyl, (3C-8C) cycloalkyl, (3C-8C)bicycloalkyl and
• —(CH2CH2O)qCH2CH2—;
• R5 is selected from the group consisting of —CH(COR6)CH2S—, —CH(COR6)CH2O—, —(CH2)4CH(COR6)NH—, —CH(COR6)CH(CH3)O—,
• and
• and,
• q is an integer from 1 to 600, inclusive.