Mutant forms of streptolysin O
AssigneeNovartis AG
InventorsGiuliano Bensi, Immaculada Margarit Y Ros, Emiliano Chiarot, Guido Grandi, Maria Scarselli
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Abstract
Forms of GAS25 (streptolysin O) which are not toxic but which still maintain the ability to induce protection against S. pyogenes are useful in vaccine compositions to induce protection against S. pyogenes.
Claims5
A purified mutant streptolysin O (SLO) protein comprising the amino acid sequence SEQ ID NO:25.
A vaccine composition comprising:
- (a) a mutant streptolysin O (SLO) protein comprising the amino acid sequence SEQ ID NO:25;
- and
- (b) a pharmaceutically acceptable carrier.
A method of making a vaccine comprising combining:
- (a) a mutant streptolysin O (SLO) protein comprising the amino acid sequence SEQ ID NO:25;
- and (b) a pharmaceutically acceptable carrier.
A method of inducing an immune response against Streptococcus pyogenes comprising administering to an individual in need thereof an effective amount of a vaccine composition comprising:
- (a) a mutant streptolysin O (SLO) protein comprising the amino acid sequence SEQ ID NO:25;
- and (b) a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.