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US 7,731,970 B2Granted
Variants of the major allergen Phl p 1 from timothy grass
AssigneeMerck Patent GmbH
InventorsRoland Suck, Helmut Fiebig, Oliver Cromwell
Life of this patent
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Abstract
The invention relates to pharmaceutically important variants of the major allergen Phl p 1 from timothy grass, characterized in that a preparation, hitherto not possible, of monomeric molecules which are soluble and stable in physiological media can be carried out with the aid of prokaryotic expression systems and subsequent purification thereof.
Claims6
An isolated polypeptide variant of major allergen Phl p 1 from timothy grass which comprises the polypeptide sequence set forth in SEQ ID NO:
- 2, wherein the variation comprises an additional Cys residue that has been introduced by exchange of Ala 236 in the wild-type Phl p 1 polypeptide sequence.
Dependencies are inferred from the claim text.