Compositions for inducing immune responses
AssigneeNovartis Vaccines and Diagnostics, Inc.
InventorsDerek O'Hagan, Manmohan Singh
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Abstract
The invention provides, inter alia, immunogenic compositions comprising a first antigen, at least two adjuvants, wherein a first adjuvant comprises a polymer derived from poly(lactides) and/or poly(lactide-co-glycolides), and wherein a second adjuvant comprises an imidazoquinoline, wherein said first antigen is encapsulated within, adsorbed or conjugated to, co-lyophilized or mixed with said first adjuvant, and a pharmaceutically acceptable excipient, wherein said composition elicits a cellular immune response when administered to a vertebrate subject. The invention also provides methods of producing immunogenic compositions, methods for producing a cytotoxic-T lymphocyte (CTL) response in a vertebrate subject, and methods of immunization.
Claims89
An immunogenic composition comprising (a) a first antigen, (b) at least two adjuvants, wherein a first adjuvant comprises poly(lactide) polymer and/or poly(lactide-co-glycolide) polymer, wherein a second adjuvant comprises an imidazoquinoline, wherein said second adjuvant is co-lyophilized with said first adjuvant and wherein the first antigen is co-lyophilized with said first adjuvant, and (c) a pharmaceutically acceptable excipient, wherein said composition elicits a cellular immune response when administered to a vertebrate subject.
Dependencies are inferred from the claim text.