Antibodies that inhibit transport activity of peptide transporters
AssigneeChugai Seiyaku Kabushiki Kaisha
InventorsTatsuhiko Kodama, Takao Hamakubo, Ryoichi Saitoh, Yoshiki Yamada
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Abstract
The present inventors discovered that the PepT-binding antibodies have the ability to inhibit the transport activity of peptide transporters, as a result of dedicated research. These antibodies may be utilized as cell growth inhibitors, for example, for treating and preventing cancer.
Claims10
A method for inhibiting peptide transporter activity, the method comprising contacting
- (a) an isolated antibody or antigen-binding fragment thereof that (i) binds to a PepT1 or PepT2 peptide transporter and (ii) inhibits peptide uptake into a cell expressing the peptide transporter, with
- (b) a cell expressing the peptide transporter,
- wherein the antibody is a monoclonal or genetically engineered recombinant antibody, and wherein the cell is in vivo.
A method for suppressing cell growth, the method comprising contacting (a) an isolated antibody or antigen-binding fragment thereof that (i) binds to a PepT1 or PepT2 peptide transporter and (ii) inhibits peptide uptake into a cell expressing the peptide transporter, with
- (b) a cell expressing the peptide transporter, wherein the antibody is a monoclonal or genetically engineered recombinant antibody, the cell is in vivo, and growth of the cell is suppressed.
Dependencies are inferred from the claim text.