US 7,731,959 B2Granted

Antagonists of neuropilin receptor function and use thereof

AssigneeChildren's Medical Center Corporation

InventorsMichael Klagsbrun, Shay Soker, Hua-Quan Miao, Seiji Takashima

Life of this patent

Estimating the term…

Abstract

The present invention relates to antagonists of neuropilin receptor fuction and use thereof in the treatment of cancer, particularly metastatic cancer, and angiogenic diseases.

Claims1

Dependent claims

A method of inhibiting angiogenesis in a host in need thereof which comprises administering to said host an effective amount of an antibody that binds a neuropilin-1 (NP-1) having the amino acid sequence set forth in SEQ ID NO:2.

Dependencies are inferred from the claim text.

Facts

Application: 10/104,440Filed 22 Mar 2002 · continuation
Priority: 9 Dec 1997
Published: US 2002/0132774 A119 Sep 2002
Granted: 8 Jun 2010
Term ends: Not estimatedThe source records don’t support an estimate.

Classification10 codes

C07K 16/2863
Against receptors, cell surface antigens or cell surface determinants: against receptors for growth factors, growth regulators
A61K 39/39558
Against materials from animals: against tumor tissues, cells, antigens
A61P 35/04
Antineoplastic agents: specific for metastasis
C07K 14/71
Receptors; Cell surface antigens; Cell surface determinants: for growth factors; for growth regulators

Family

Application60/069,155Us provisional application · filed 9 Dec 1997
Application60/069,687Us provisional application · filed 12 Dec 1997
Application60/078,541Us provisional application · filed 19 Mar 1998
PCT/US98/26114Parent of this continuation · filed 9 Dec 1998
Application09/580,803Parent of this continuation · filed 30 May 2000
US 2002/0132774 A1Pre-grant publication · published 19 Sep 2002
US 7,731,959 B2This patent

From the US filing history. Foreign family members aren’t listed.

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