Compositions and methods of using chondroitinase ABCI mutants
AssigneeAcorda Therapeutics, Inc.
InventorsAnthony O. Caggiano, Jennifer Iaci, Andrea Vecchione, Elizabeth Markensohn
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Abstract
One aspect of the present invention relates to mutants of chondroitinase ABCI. Such chondroitinase ABCI mutants exhibit altered chondroitin lyase activity or increased resistance to inactivation from stressors including exposure to UV light or heat. Methods of using chondroitinase ABCI mutant enzymes are also provided.
Claims13
An isolated mutant chondroitinase ABCI enzyme comprising the amino acid sequence of SEQ ID NO:
- 1.
A method of treating a central nervous system injury comprising administering a therapeutically effective amount of an isolated mutant chondroitinase ABCI enzyme comprising the amino acid sequence of SEQ ID NO:
- 1.
A method of promoting neuronal outgrowth comprising administering a therapeutically effective amount of an isolated mutant chondroitinase ABCI enzyme comprising the amino acid sequence of SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.