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US 7,731,954 B2Granted
Wound dressings comprising hydrated hydrogels and enzymes
AssigneeInsense Limited
InventorsPaul James Davis, Andrew John Austin
Life of this patent
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AssigneeInsense Limited
InventorsPaul James Davis, Andrew John Austin
Estimating the term…
A skin dressing, particularly a wound dressing, comprises oxidoreductase enzyme and, optionally, peroxidase enzyme, wherein the enzyme(s) are present in hydrated condition, e.g. being present in one or more hydrated hydrogels. The dressing is used by being located on the skin of a human or animal e.g. over a wound. The oxidoreductase enzyme catalyses a reaction that produces hydrogen peroxide from an appropriate substrate, the substrate either being naturally present in body fluids and/or being supplied separately and/or being incorporated into the dressing. The currently preferred oxidoreductase enzyme is glucose oxidase. The catalyses reaction of β-D-glucose substrate to give hydrogen peroxide and gluconic acid. A mixture of oxidoreductase enzyme can undergo reaction (optionally catalysed by the peroxidase enzyme) to produce a variety of species including reactive oxygen intermediates that have antimicrobial properties and that can therefore assist in promoting wound healing.
A skin dressing comprising a layered construction, said layered construction including one or more oxidoreductase enzymes in hydrated condition and present in sufficient amount to catalyze, in the presence of appropriate substrate, the conversion of atmospheric oxygen to hydrogen peroxide for transmittal through the dressing to the skin, wherein at least the enzyme-containing layer of the dressing is sealed in packaging and maintained in hydrated and sterile condition in said packaging up to use, wherein said layered construction comprises an upper layer and a lower layer, said upper layer being remote from the skin in use and including the oxidoreductase enzyme, and said lower layer being below the upper layer in use such that hydrogen peroxide which is formed and transported through the dressing is discharged at the skin for conversion to oxygen, said lower layer comprising a hydrogel including said source of substrate for the oxidoreductase enzyme, said oxidoreductase enzyme being included only in said upper layer and remaining in the upper layer in use.
A layered dressing for treatment of skin wounds comprising
Dependencies are inferred from the claim text.