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US 7,731,948 B2Granted
Stabilized interferon liquid formulations
AssigneeAres Trading S.A.
InventorsFabrizio Samaritani, Alessandra Del Rio
Life of this patent
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Abstract
A stabilized HSA-free liquid pharmaceutical composition is described, which comprises an interferon (IFN), wherein said formulation is a solution that comprises a buffer, an amino acid and an antioxidant. Preferably, the interferon is human recombinant IFN-beta.
Claims2
A composition comprising:
- a) about 88 μg/ml interferon-beta 1a
- b) about 27.3 mg/ml lysine;
- c) about 0.12 mg/ml methionine;
- d) about 0.5 mg/ml poloxomer 188;
- and
- c) an aqueous acetate buffer at a pH of 3.5 to 5.5.
3 more elements
A composition comprising interferon-beta 1a, lysine, methionine and poloxomer 188 in an aqueous acetate buffer having a pH of about 3.4 to 5.5, said composition containing interferon-beta 1a, lysine, methionine and poloxomer 188 at a ratio of interferon-beta 1a:lysine:methionine:poloxomer 188 of about:
- 1:310:1.4:5.7.
Dependencies are inferred from the claim text.