Implant for subcutaneous or intradermal injection
AssigneeAventis Pharmaceuticals Holdings, Inc.
InventorsJérôme Asius, Hatem Fessi, Franck Gouchet, Bénedicte Laglenne, Elisabeth Laugier-Laglenne
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Abstract
The invention concerns an injection implant for filling up wrinkles, thin lines, skin cracks and scars, for reparative or plastic surgery, aesthetic dermatology, and for filling up gums in dental treatment. The invention concerns the use of biologically absorbable polymer microspheres or microparticles suspended in a gel. Said suspension is produced either ready-for-use or freeze-dried. The biological absorbability of the microspheres is controlled and enables the production of implants having well defined persistence and deliberately limited to 3 years.
Claims15
A reconstitutable product, which upon the addition of water becomes a bioresorbable, injectable implant product, wherein said reconstitutable product comprises a freeze-dried composition of:
- microparticles of at least one polymer of non-animal origin selected from the group consisting of lactic acid polymers, glycolic acid polymers, and lactic acid-glycolic acid co-polymers;
- and
- a hydrogel precursor consisting essentially of materials of non-animal origin, wherein said precursor forms a hydrogel upon the addition of water.
A reconstitutable bioresorbable injectable implant product made by freeze-drying a composition consisting essentially of:
- bioresorbable microspheres or microparticles suspended in a gel, said gel consisting essentially of materials of non-animal origin,
- said microspheres or microparticles consisting of at least one polymer of non-animal origin selected from the group consisting of lactic acid polymers, glycolic acid polymers, and lactic acid-glycolic acid co-polymers.
A kit comprising a syringe prefilled with a bioresorbable injectable implant for human administration consisting essentially of:
- bioresorbable microspheres or microparticles suspended in a gel, said gel consisting essentially of materials of non-animal origin,
- said microspheres or microparticles consisting of at least one polymer of non-animal origin selected from the group consisting of lactic acid polymers, glycolic acid polymers, and lactic acid-glycolic acid co-polymers.
Dependencies are inferred from the claim text.