US 7,728,153 B2 · Method for the asymmetric synthesis of beta-lactone compounds

Abstract

The present invention features methods of treating a cancer in a subject by administering an effective amount of a beta-lactone to the subject. The invention also features methods of inhibiting angiogenesis in a subject by administering an effective amount of an inhibitor of fatty acid synthase to the subject. These methods can be used to treat a variety of cancers and other diseases and conditions. The invention also features methods of identifying beta-lactones and other compounds that can be used in the methods of the invention for the treatment of tumors, inhibition of angiogenesis, and the treatment of diseases and conditions that involve pathological angiogenesis. The invention also features methods of synthesizing beta-lactones and features novel beta-lactone compounds.

Claims21

Dependent claims

A method for the asymmetric synthesis of beta-lactone compounds comprising the steps of:

(a) forming a ketene dimer from an acid chloride, in the presence of a catalyst, wherein the catalyst is selected from the group consisting of QND, O-TBS QND, O-TMS QND, and O-TMS QUIN;
and
(b) hydrogenating the ketene dimer to generate a cis-beta-lactone in the presence of a catalyst.

Dependencies are inferred from the claim text.

Facts

Application

11/378,961Filed 16 Mar 2006 · continuation in part

Priority

16 Apr 2003

Published

US 2006/0258620 A116 Nov 2006

Granted

1 Jun 2010

Term ends

Not estimatedThe source records don’t support an estimate.

Classification13 codes

A61K 31/336
Having oxygen as the only ring hetero atom, e.g. fungichromin: having three-membered rings, e.g. oxirane, fumagillin
A61K 31/335
Heterocyclic compounds: having oxygen as the only ring hetero atom, e.g. fungichromin
A61K 31/337
Having oxygen as the only ring hetero atom, e.g. fungichromin: having four-membered rings, e.g. taxol
A61K 31/365
Having oxygen as the only ring hetero atom, e.g. fungichromin: lactones

Family

Application10/418,513Parent of this continuation-in-part · filed 16 Apr 2003

US 2006/0258620 A1Pre-grant publication · published 16 Nov 2006

US 2004/0024050 A1Published application

US 7,799,826 B2Related patent

US 7,728,153 B2This patent

From the US filing history. Foreign family members aren’t listed.

Method for the asymmetric synthesis of beta-lactone compounds

Life of this patent

Method for the asymmetric synthesis of beta-lactone compounds

Life of this patent

Abstract

Claims21