Drug depot implant designs
AssigneeWarsaw Orthopedic, Inc.
InventorWilliam F. McKay
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Abstract
The present invention relates to novel drug depot implant designs for optimal delivery of therapeutic agents to subjects. The invention provides a method for alleviating pain associated with neuromuscular or skeletal injury or inflammation by targeted delivery of one or more therapeutic agents to inhibit the inflammatory response which ultimately causes acute or chronic pain. Controlled and directed delivery can be provided by drug depot implants, comprising therapeutic agents, specifically designed to deliver the therapeutic agent to the desired location by facilitating their implantation, minimizing their migration from the desired tissue location, and without disrupting normal joint and soft tissue movement.
Claims17
A drug depot implant comprising:
- a body having a surface and opposites sides;
- an anchoring system extending from the body, the anchoring system comprising at least two angled flexible barbs, each of the at least two angled flexible barbs comprising a point adapted to allow forward translational movement of the body and limit backward translational movement of the body from a targeted tissue, wherein the at least two angled flexible barbs are on the surface of the body and the at least two angled flexible barbs are located on opposite sides of the body;
- and
- a therapeutic agent comprising a NFkB inhibitor disposed throughout the body and the anchoring system, wherein the body and the anchoring system are capable of eluting the therapeutic agent and the drug depot implant is solid and provides an optimal concentration of the therapeutic agent from 1 cm to 5 cm from the drug depot implant.
A solid drug depot implant comprising:
- a rod-shaped body having a surface and opposite sides;
- an anchoring system extending from the rod-shaped body, the anchoring system adapted to limit movement of the rod-shaped body from a targeted tissue, the anchoring system comprising at least four barbs on the surface of the rod-shaped body, a first pair of the at least four barbs located on opposite sides of the rod-shaped body, each barb of the first pair comprising a point adapted to limit backward movement of the body from a targeted tissue and a second pair of the at least four barbs located on opposites sides of the rod-shaped body, each barb of the second pair comprising a point adapted to limit forward movement of the body from a targeted tissue;
- and
- a therapeutic agent comprising a NFkB inhibitor disposed throughout the rod-shaped body and the anchoring system, wherein the rod-shaped body and anchoring system are capable of eluting the therapeutic agent.
Dependencies are inferred from the claim text.