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US 7,727,534 B2Granted
Reovirus clearance of ras-mediated neoplastic cells from mixed cellular compositions
AssigneeOncolytics Biotech Inc.
InventorsDonald Morris, Bradley G. Thompson, Matthew C. Coffey
Life of this patent
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Abstract
Reovirus can be used to selectively remove ras-mediated neoplastic cells from a cellular composition. It is of particular interest to purge autographs which may contain neoplastic cells with reovirus before transplanting the autographs back into the recipient, thereby reducing the risk of introducing or reintroducing neoplastic cells into the recipient.
Claims20
A method for transplanting a cellular composition into a mammal, comprising the steps of:
- a) administering a reovirus to the mammal in an amount sufficient to elicit an immune response to the reovirus in the mammal, and
- b) transplanting into the mammal a cellular composition that has been purged with the reovirus.
Dependencies are inferred from the claim text.