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US 7,726,319 B1Granted
Method for removal of water associated with bone while diminishing the dimensional changes associated with lyophilization
AssigneeOsteotech, Inc.
InventorTodd M. Boyce
Life of this patent
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Abstract
A method for dehydrating a monolithic bone intended for implantation is provided. The method serves to conserve at least one of the biomechanical properties of the bone during the dehydration of the bone and its subsequent packaging. Also provided is a monolithic bone for implantation and a method of using the bone for the repair of damaged bone.
Claims17
A method for dehydrating monolithic bone intended for implantation to conserve toughness of the bone during dehydration and subsequent packaging and maintain such toughness during storage of the bone, the method comprising:
- dehydrating the monolithic bone to less than about 6 percent water content wherein dehydrating the monolithic bone consists of contacting the bone with at least one biocompatible dehydrating liquid and controlling pressure surrounding the monolithic bone during such contact;
- removing the dehydrating liquid;
- and packaging the dehydrated bone, wherein dehydrating the monolithic bone to less than about 6 percent water content is accomplished without lyophilizing, freeze drying, or oven drying the bone and wherein the conserved bone toughness is at least about 10% greater than that of a comparable specimen of monolithic bone which has been lyophilized.
Dependencies are inferred from the claim text.