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US 7,723,483 B2Granted
Method for enhancing or inhibiting insulin-like growth factor-I
AssigneeThe University of North Carolina at Chapel Hill
InventorsDavid R. Clemmons, Laura A. Maile
Life of this patent
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Abstract
The present invention provides αVβ3 integrin cysteine loop domain agonists and antagonists (including peptide agonists and antagonists and analogs thereof), along with methods of using the same.
Claims17
An isolated antibody that:
- (a) specifically binds to the cysteine loop domain at amino acids 177 to 184 of a human β3 integrin, wherein said amino acids consist of SEQ ID NO:
- 82;
- (b) does not specifically bind to the RGD binding site of a human β3 integrin or utilize the RGD binding site of human β3 integrin;
- and (c) specifically binds to the cysteine loop domain at amino acids 177 to 184 of a pig β3 integrin, wherein said amino acids consist of SEQ ID NO:
- 82.
2 more elements
A monoclonal antibody that:
- (a) specifically binds to the cysteine loop domain at amino acids 177 to 184 of a human β3 integrin, wherein said amino acids consist of SEQ ID NO:
- 82;
- (b) does not specifically bind to the RGD binding site of a human β3 integrin or utilize the RGD binding site of the human β3 integrin;
- and (c) specifically binds to the cysteine loop domain at amino acids 177 to 184 of a pig β3 integrin, wherein said amino acids consist of SEQ ID NO:
- 82.
2 more elements
An isolated antibody that:
- (a) specifically binds to the cysteine loop domain at amino acids 177 to 184 of a human β3 integrin, wherein said amino acids consist of SEQ ID NO:
- 82;
- (b) does not specifically bind to the RGD binding site of a human β3 integrin or stimulate the specific biochemical events that are stimulated by peptides that bind to the RGD binding site of human β3 integrin;
- and (c) specifically binds to the cysteine loop domain at amino acids 177 to 184 of a pig β3 integrin, wherein said amino acids consist of SEQ ID NO:
- 82.
2 more elements
A monoclonal antibody that:
- (a) specifically binds to the cysteine loop domain at amino acids 177 to 184 of a human β3 integrin, wherein said amino acids consist of SEQ ID NO:
- 82;
- (b) does not specifically bind to the RGD binding site of a human β3 integrin or stimulate the specific biochemical events that are stimulated by peptides that bind to the RGD binding site of human β3 integrin;
- and (c) specifically binds to the cysteine loop domain at amino acids 177 to 184 of a pig β3 integrin, wherein said amino acids consist of SEQ ID NO:
- 82.
2 more elements
Dependencies are inferred from the claim text.