Fluoride carrier for positron emission tomography

A compound having the formula:

• wherein
• R1 is
• wherein
• R2a, R2b, R3a and R3b are each hydrogen;
• R4a and R5a and R4b and R5b are each hydrogen, or combined to form ═O;
• each R6 is independently a member selected from the group consisting of H, optionally substituted C1-C10 alkyl, C1-C6 alkyl-CO2H, C1-C6 alkyl-CONHR7, optionally substituted C6-C12 aryl and L, wherein L is a linker selected from the group consisting of
• each R7 is independently a member selected from the group consisting of H and C1-C6 alkyl;
• or R4a, R5a and R6 or R4b, R5b and R6 are combined to form a 5-6 membered heteroaryl ring having from 1-3 heteroatoms each independently selected from the group consisting of N, O and S, optionally substituted with 1-3 R8;
• or R2a, R2b, R3a, R3b, R4a, R4b, R5a, R5b and R6 are combined to form a 11-14 membered heteroaryl ring having from 1-3 heteroatoms each independently selected from the group consisting of N, O and S, optionally substituted with 1-3 R8;
• each R8 is independently a member selected from the group consisting of H, optionally substituted C1-C6 alkyl, optionally substituted C5-C10 cycloalkyl, optionally substituted C6-C12 aryl, optionally substituted C5-C12 heteroaryl and L;
• wherein the substituted alkyl and substituted cycloalkyl groups are substituted with a member selected from the group consisting of —OR′, ═O, ═NR′, ═N—OR′, —NR′R″, —SR′, -halogen, —SiR′R″R′″, —OC(O)R′, —C(O)R′, —CO2R′, —CONR′R″, —OC(O)NR′R″, —NR″C(O)R′, —NR′—C(O)NR″R′″, —NR″C(O)2R′, —NH—C(NH2)═NH, —NR′C(NH2)═NH, —NH—C(NH2)═NR′, —S(O)R′, —S(O)2R′, —S(O)2NR′R″, —CN and —NO2, wherein R′, R″and R′″ are each independently selected from the group consisting of hydrogen, unsubstituted (C1-C8)alkyl and heteroalkyl, unsubstituted aryl, unsubstituted alkyl, alkoxy or thioalkoxy groups, or aryl-(C1-C4)alkyl groups;
• wherein the substituted aryl and substituted heteroaryl groups are substituted with a member selected from the group consisting of -halogen, —OR′, —OC(O)R′, —NR′R″, —SR′, —R′, —CN, —NO2, —CO2R′, —CONR′R″, —C(O)R′, —OC(O)NR′R″, —NR″C(O)R′, —NR″C(O)2R′, —NR′—C(O)NR″R′″, —NH—C(NH2)═NH, —NR′C(NH2)═NH, —NH—C(NH2)═NR′, —S(O)R′, —S(O)2R′, —S(O)2NR′R″, —N3, —CH(Ph)2, perfluoro(C1-C4)alkoxy, and perfluoro(C1-C4)alkyl, wherein R′, R″ and R′″ are independently selected from the group consisting of hydrogen, (C1-C8)alkyl and heteroalkyl, unsubstituted aryl and heteroaryl, (unsubstituted aryl)-(C1-C4)alkyl, and (unsubstituted aryl)oxy-(C1-C4)alkyl;
• and pharmaceutically acceptable salts and isomers thereof.