Inclusion compounds of fumagillol derivative or its salt, and pharmaceutical compositions comprising the same
AssigneeChong Kun Dang Pharmaceutical Corp.
InventorsJae Hyun Kim, Su Kyung Lee, Won Kyu Choi, Jong Lae Lim, Soon Kil Ahn, Hee Jong Shin, Chung Il Hong
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Abstract
The present invention relates to an inclusion compound of fumagillol derivative or its salt with hydroxypropyl-β-cyclodextrin or sulfobutylether-7-β-cyclodextrin, and pharmaceutical compositions comprising the same. The inclusion compound according to the present invention has superior water solubility and stability while exhibiting low toxicity, rendering it valuable as an anticancer agent or inhibitor of tumor metastasis.
Claims21
An inclusion compound of a fumagillol derivative or a salt thereof, and hydroxypropyl-β-cyclodextrin or sulfobutylether-7-β-cyclodextrin:
- wherein said fumagillol derivative or its salt is O-(4-dimethylaminoethoxycinnamoyl)fumagillol or O-(3,4,5-trimethoxycinnamoyl)fumagillol.
An inclusion compound of O-(4 dimethylaminoethoxycinnamoyl)fumagillol or a salt thereof;
- and hydroxypropyl-β-cyclodextrin or sulfobutylether-7-β-cyclodextrin.
An inclusion compound of O-(3,4,5-trimethoxycinnamoyl)fumagillol;
- and hydroxypropyl-β-cyclodextrin or sulfobutylether-7-β-cyclodextrin.
Dependencies are inferred from the claim text.