Methods for preventing or treating ischemia-reperfusion injury of the kidney

A method for treating or preventing ischemia-reperfusion injury of the kidney in a mammal, the method comprising administering to the mammal an effective amount of a peptide having the formula selected from the group consisting of:

• D-Arg-2′,6′-Dmt-Lys-Phe-NH2,
• D-Arg-2′,6′-Dmt-Phe-Lys-NH2,
• D-Arg-Phe-Lys-2′,6′-Dmt-NH2,
• D-Arg-Phe-2′,6′-Dmt-Lys-NH2,
• D-Arg-Lys-2′,6′-Dmt-Phe-NH2,
• D-Arg-Lys-Phe-2′,6′-Dmt-NH2,
• Phe-Lys-2′,6′-Dmt-D-Arg-NH2,
• Phe-Lys-D-Arg-2′,6′-Dmt-NH2,
• Phe-D-Arg-2′,6′-Dmt-Lys-NH2,
• Phe-D-Arg-Lys-2′,6′-Dmt-NH2,
• Phe-D-Arg-Phe-Lys-NH2,
• Phe-2′,6′-Dmt-D-Arg-Lys-NH2,
• Phe-2′,6′-Dmt-Lys-D-Arg-NH2,
• Dmp-D-Arg-Phe-Lys-NH2,
• Lys-Phe-2′,6′-Dmt-D-Arg-NH2,
• Lys-2′,6′-Dmt-D-Arg-Phe-NH2,
• Lys-2′,6′-Dmt-Phe-D-Arg-NH2,
• Lys-D-Arg-Phe-2′,6′-Dmt-NH2,
• Lys-D-Arg-2′,6′-Dmt-Phe-NH2,
• D-Arg-2′,6′-Dmt-D-Arg-Phe-NH2,
• D-Arg-2′,6′-Dmt-D-Arg-2′,6′-Dmt-NH2,
• D-Arg-2′,6′-Dmt-D-Arg-Tyr-NH2,
• D-Arg-2′,6′-Dmt-D-Arg-Trp-NH2,
• Trp-D-Arg-Phe-Lys-NH2,
• Trp-D-Arg-Tyr-Lys-NH2,
• Trp-D-Arg-Trp-Lys-NH2,
• Trp-D-Arg-Dmt-Lys-NH2,
• D-Arg-Trp-Lys-Phe-NH2,
• D-Arg-Trp-Phe-Lys-NH2,
• D-Arg-Trp-Lys-Dmt-NH2,
• D-Arg-Trp-Dmt-Lys-NH2,
• D-Arg-Lys-Trp-Phe-NH2,
• D-Arg-Lys-Trp-Dmt-NH2,
• Cyclohexyl-D-Arg-Phe-Lys-NH2,
• Ala-D-Arg-Phe-Lys-NH2,
• Lys-D-Arg-Tyr-NH2,
• Trp-D-Lys-Tyr-Arg-NH2,
• Phe-Arg-D-His-Asp,
• Met-Tyr-D-Lys-Phe-Arg (SEQ. ID. NO:
• 4),
• D-His-Glu-Lys-Tyr-D-Phe-Arg (SEQ. ID. NO:
• 5),
• Lys-D-Gln-Tyr-Arg-D-Phe-Trp-NH2 (SEQ. ID. NO:
• 6),
• Phe-D-Arg-Lys-Trp-Tyr-D-Arg-His (SEQ. ID. NO:
• 7),
• Gly-D-Phe-Lys-Tyr-His-D-Arg-Tyr-NH2 (SEQ. ID. NO:
• 8),
• Val-D-Lys-His-Tyr-D-Phe-Ser-Tyr-Arg-NH2 (SEQ. ID. NO:
• 9),
• Trp-Lys-Phe-D-Asp-Arg-Tyr-D-His-Lys (SEQ. ID. NO:
• 10),
• Lys-Trp-D-Tyr-Arg-Asn-Phe-Tyr-D-His-NH2 (SEQ. ID. NO:
• 11),
• Thr-Gly-Tyr-Arg-D-His-Phe-Trp-D-His-Lys (SEQ. ID. NO:
• 12),
• Asp-D-Trp-Lys-Tyr-D-His-Phe-Arg- D-Gly-Lys-NH2 (SEQ. ID. NO:
• 13),
• D-His-Lys-Tyr-D-Phe-Glu-D-Asp-D-His-D-Lys-Arg-Trp-NH2 (SEQ. ID. NO:
• 14),
• Ala-D-Phe-D-Arg-Tyr-Lys-D-Trp-His-D-Tyr-Gly-Phe (SEQ. ID. NO:
• 15),
• Phe-Phe-D-Tyr-Arg-Glu-Asp-D-Lys-Arg-D-Arg-His-Phe-NH2 (SEQ. ID. NO:
• 17),
• Phe-Tyr-Lys-D-Arg-Trp-His-D-Lys-D-Lys-Glu-Arg-D-Tyr-Thr (SEQ. ID. NO:
• 18),
• Glu-Arg-D-Lys-Tyr-D-Val-Phe-D-His-Trp-Arg-D-Gly-Tyr-Arg-D-Met-NH2 (SEQ. ID. NO:
• 20),
• Arg-D-Leu-D-Tyr-Phe-Lys-Glu-D-Lys-Arg-D-Trp-Lys-D-Phe-Tyr-D-Arg-Gly (SEQ. ID. NO:
• 21),
• D-Glu-Asp-Lys-D-Arg-D-His-Phe-Phe-D-Val-Tyr-Arg-Tyr-D-Tyr-Arg-His-Phe-NH2 (SEQ. ID. NO:
• 22),
• Asp-Arg-D-Phe-Cys-Phe-D-Arg-D-Lys-Tyr-Arg-D-Tyr-Trp-D-His-Tyr-D-Phe-Lys-Phe (SEQ. ID. NO:
• 23),
• His-Tyr-D-Arg-Trp-Lys-Phe-D-Asp-Ala-Arg-Cys-D-Tyr-His-Phe-D-Lys-Tyr-His-Ser-NH2 (SEQ. ID. NO:
• 24),
• Gly-Ala-Lys-Phe-D-Lys-Glu-Arg-Tyr-His-D-Arg-D-Arg-Asp-Tyr-Trp-D-His-Trp-His-D-Lys-Asp (SEQ. ID. NO:
• 25), and
• Thr-Tyr-Arg-D-Lys-Trp-Tyr-Glu-Asp-D-Lys-D-Arg-His-Phe-D-Tyr-Gly-Val-Ile-D-His-Arg-Tyr-Lys-NH2 (SEQ. ID. NO:
• 26).