# US 7,717,853 B2 · Methods and apparatus for intracranial ultrasound delivery > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 7,717,853 B2 - Document ID: US7717853B2 - Status: Granted - Kind: B2 - Application number: 11/203,738 - Filed: 2005-08-15 - Published: 2007-01-18 - Granted: 2010-05-18 - Earliest claimed: 2005-08-15 - Inventors: Henry Nita - Web page: https://patentgrep.com/patent/US7717853B2 ## CPC - A61N 7/00: Ultrasound therapy (lithotripsy A61B17/22, A61B17/225; massage using supersonic vibration A61H23/00 {; using ultrasound for introducing media into the body A61M37/0092}) - A61N 7/022: {intracavitary} - A61B 8/0808: {for diagnosis of the brain} - A61B 90/11: with guides for needles or instruments, e.g. arcuate slides or ball joints - A61B 2017/22008: {used or promoted} - A61N 2007/0047: {interstitial} - A61N: ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY (measurement of bioelectric currents A61B; surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body A61B18/00; anaesthetic apparatus in general A61M; incandescent lamps H01K; infrared radiators for heating H05B) - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) ## Abstract A method for delivering ultrasound energy to a patient's intracranial space involves forming at least one hole in the patient's skull, advancing at least one ultrasound delivery device at least partway through the hole(s), and transmitting ultrasound energy from the ultrasound delivery device(s). According to various embodiments, ultrasound delivery devices may be advanced into the epidural space, one or both ventricles and/or an intracerebral space of the patient's brain. In alternative embodiments, one or multiple holes may be formed in the skull, and any number of ultrasound delivery devices may be used. Intracranial ultrasound delivery may be used in diagnostic or therapeutic treatment of ischemic stroke, head trauma, atherosclerosis, perfusion disorders and other acute or chronic neurological conditions. ## Claims ### Claim 1 A method for delivering ultrasound energy to a patient's intracranial space, the method comprising: forming at least one hole in the patient's skull to access a target location; advancing at least one ultrasound device having a distal portion through the hole, wherein the distal portion contains at least one transducer to allow transmission of ultrasound, and the distal portion can be moved to various locations within the intracranial space without causing damage; transmitting ultrasound energy at frequencies between 20 Khz and 10 MHz from the ultrasound delivery device for therapeutic treatment; wherein the ultrasound energy is transmitted and directed from outside a blood vessel to a blood clot in the patient's brain at the target location that resides in an intracerebral space of the patient's brain, inside of the blood vessel, to disrupt the blood clot; further comprising placing an introducer device into the at least one hole, with the at least one ultrasound delivery device advanced through the introducer device. ### Claim 2 (depends on 1) The method of claim 1, wherein advancing the ultrasound device comprises advancing a device selected from the group consisting of an ultrasound transducer and a transducer-tipped ultrasound catheter. ### Claim 3 (depends on 1) The method of claim 1, wherein the ultrasound energy is transmitted acutely. ### Claim 4 (depends on 1) The method of claim 1, wherein the ultrasound energy is transmitted chronically. ### Claim 5 (depends on 1) The method of claim 1, further comprising delivering at least one pharmacologic agent to the patient. ### Claim 6 (depends on 5) The method of claim 5, wherein the agent is selected from a group consisting of blood clot reducing agents such as tissue plasminogen activator, rTPA, Urokinease, Streptokinase, Alteplase and Desmoteplase, antiplatelet agents such as aspirin, Clopidorgel and Ticciopidine, and GIIb/IIIa inhibitors, such as Abciximab, Tirofiban and Eptifibatide. ### Claim 7 (depends on 5) The method of claim 5, wherein delivering the agent comprises using a method selected from the group consisting of intravenous, arterial and oral delivery. ### Claim 8 (depends on 1) The method of claim 1, further comprising delivering microbubbles or nanobubbles into the patient's bloodstream. ### Claim 9 (depends on 8) The method of claim 8, wherein the microbubbles or nanobubbles are delivered intravenously or arterially. ### Claim 10 (depends on 8) The method of claim 8, further comprising providing at least one pharmacologic agent to the patient. ### Claim 11 (depends on 10) The method of claim 10, wherein the microbubbles or nanobubbles and pharmacological agent are delivered in combination or sequentially. ### Claim 12 (depends on 1) The method of claim 1, further including transmitting the ultrasound energy to a blood vessel in the patient's brain to help treat atherosclerosis of the blood vessel. ### Claim 13 (depends on 1) The method of claim 1, further including transmitting the ultrasound energy to one or more blood vessels in the brain to help treat a blood perfusion abnormality in the patient's brain. ### Claim 14 (depends on 1) The method of claim 1, further providing a conductive medium which interfaces between the ultrasound transducer and the patient. ### Claim 15 (depends on 14) The method of claim 14, further including providing the conductive medium in the form of a compliant pack. ### Claim 16 (depends on 15) The method of claim 15, further providing a gel or oil inside the pack. ### Claim 17 (depends on 1) The method of claim 1, further providing a conductive medium which interfaces between the ultrasound transducer and the patient. ### Claim 18 (depends on 1) The method of claim 1, further including transmitting ultrasound energy for cerebrovascular diagnostics. ### Claim 19 (depends on 1) The method of claim 1, further including transmitting ultrasound energy for cerebrovascular diagnostics and therapeutic treatment.