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AssigneeGE Healthcare Bio-Sciences AB
InventorsCarina Engstrand, Annika Forss, Gunnar Glad, Bo-Lennart Johansson, Hans J. Johansson, Jean-Luc Maloisel
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The present invention relates to a method of separating antibodies from other compound(s) in a liquid sample, wherein a mobile phase comprising said sample is contacted with a multi-modal separation matrix to adsorb undesired compounds while the antibodies remain free in the liquid, wherein the multi-modal separation matrix comprises first groups, which are capable of interacting with negatively charged sites of the target compounds, and second groups, which are capable of at least one interaction other than charge-charge interaction with said target compounds. The invention also relates to a chromatography column packed with the above-described multi-modal separation matrix and a filter having such multi-modal groups adsorbed to its surface.
A method for separating one or more antibodies from one or more other compounds in a liquid sample, which method comprises contacting a mobile phase comprising said liquid sample with a multi-modal separation matrix to adsorb one or more of said other compounds while the antibodies remain free in the mobile phase, wherein the multi-modal separation matrix comprises first groups capable of interacting with negatively charged sites of said other compound(s) and second groups capable of at least one interaction other than charge-charge interaction with said other compound(s).
Dependencies are inferred from the claim text.