Acidic insulin preparations having improved stability
AssigneeSanofi-Aventis Deutschland GmbH
InventorsAnette Brunner-Schwarz, Norbert Lill
Life of this patent
Estimating the term…
Abstract
The invention relates to a pharmaceutical formulation comprising a polypeptide selected from the group consisting of insulin, an insulin metabolite, an insulin analog, an insulin derivative and combinations thereof; a surfactant or combinations of two or more surfactants; optionally a preservative or combinations of two or more preservatives; and optionally an isotonicizing agent, buffers or further excipients or combinations thereof, the pharmaceutical formulation having a pH in the acidic range.
Claims20
A pharmaceutical formulation comprising Gly(A21), Arg(B31), Arg(B32)-human insulin;
- at least one chemical entity chosen from esters and ethers of polyhydric alcohols;
- at least one preservative;
- and
- water,
- wherein the pharmaceutical formulation has a pH in the acidic range from 1 to 6.8.
The pharmaceutical formulation as claimed in claimed 6, wherein the pharmaceutical formulation has a pH in the acidic range from 3.5 to 4.5.
Dependencies are inferred from the claim text.