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US 7,713,703 B1Granted
Methods for monitoring the status of assays and immunoassays
AssigneeBiosite, Inc.
InventorsKenneth F. Buechler, Joseph M Anderberg, Paul H. McPherson
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Abstract
The invention relates in part to the use of independent assay controls (IACs) for the optical communication between an assay device and an instrument in monitoring and performing assays, preferably immunoassays.
Claims15
An apparatus for measuring progress and time of completion of an assay in an assay device, comprising:
- (a) said assay device comprising
- a reaction chamber and
- at least one diagnostic lane, wherein a label is provided in said reaction chamber;
- (b) an optical component for detecting a signal generated from said label in at least one discrete zone of said diagnostic lane;
- and
- (c) a signal processor for determining said progress and time of completion of said assay in said assay device from at least one parameter selected from the group consisting of a rate of change of the amount of said signal and an absolute amount of said signal;
- wherein the label does not appreciably bind to assay reagents in said assay device.
4 more elements
A kit for measuring progress and time of completion of an assay in an assay device, comprising:
- (a) instructions comprising text or diagrams about the apparatus and/or kit;
- and
- (b) an apparatus, comprising:
- (i) said assay device comprising
- a reaction chamber and
- at least one diagnostic lane, wherein a label is provided in said reaction chamber;
- (ii) an optical component for detecting a signal generated from said label in at least one discrete zone of said diagnostic lane;
- and
- (iii) a signal processor for determining said progress and time of completion of said assay in said assay device from at least one parameter selected from the group consisting of a rate of change of the amount of said signal and an absolute amount of said signal;
- wherein the label does not appreciably bind to assay reagents in said assay device.
7 more elements
An apparatus for measuring progress and time of completion of an assay in an assay device, comprising:
- (a) said assay device comprising
- a reaction chamber, and
- at least one diagnostic lane, wherein said diagnostic lane is in fluid communication with said reaction chamber when fluid and a detectable label are added to said reaction chamber;
- (b) an optical component for detecting a signal generated from said label in at least one discrete zone of said diagnostic lane;
- and
- (c) a signal processor for determining said progress and time of completion of said assay in said assay device from at least one parameter selected from the group consisting of a rate of change of the amount of said signal and an absolute amount of said signal;
- wherein the label does not appreciably bind to assay reagents in said assay device.
4 more elements
Dependencies are inferred from the claim text.