Imines as ion channel modulators

A compound having a structure according to Formula (I):

• or pharmaceutically acceptable salts thereof, wherein
• X is H, substituted or unsubstituted alkyl or —NR2R3,
• Y is H or —OR7;
• Z1, Z2, and Z3 are independently H, hydroxyl, amino, cyano, nitro, halogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, —SR4b, —OR5b, —P(O)R10aR11a, —S(O)q1R12a, or —PR14R15, wherein q1 is an integer selected from 1 and 2;
• h, j, and k are integers independently selected from 1 to 5;
• R2is H, hydroxyl, amino, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heteroalkyl, or substituted or unsubstituted heterocycloalkyl;
• R3 is H, hydroxyl, amino, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted heterocycloalkyl, —P(O)R10cR11c, —S(O)q3Rl12C, or —C(O)R17b,
• wherein q3 is an integer selected from 1 and 2, and
• wherein R2 and R3 are optionally joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl with the nitrogen to which they are attached;
• R4b is H, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heteroalkyl, or substituted or unsubstituted heterocycloalkyl;
• R5b is H, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted heterocycloalkyl, —P(O)R10dR11d, or —S(O)q4R12d, wherein q4 is an integer selected from 1 and 2;
• R7 is H, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted heterocycloalkyl, or —P(O)R10fR11f and;
• R10a, R10c, R10d, R10f, R11a, R11c, R11d and R11f are independently amino, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or —OR16, wherein
• R16 is independently H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl,
• wherein R10a and R11a, R10c and R11c, R10d and R11d, R10f and R11f are not simultaneously amino;
• R12a, R12c or R12d is independently amino, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R14 and R15 are independently substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• and
• R17b is H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or —OR8, wherein
• R18 is H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl
• wherein Y and X, together with the atoms to which they are attached, are optionally joined to form a substituted or unsubstituted ring;
• wherein Z1 and X, together with the atoms to which they are attached, are optionally joined to form a bicyclic fused ring;
• wherein Z3 and X, together with the atoms to which they are attached, are optionally joined to form a bicyclic fused ring;
• wherein Z1 and Z2, together with the atoms to which they are attached, are optionally joined to form a tricyclic fused ring;
• wherein Z1 and Z3, together with the atoms to which they are attached, are optionally joined to form a tricyclic fused ring;
• and
• wherein Z2 and Z3, together with the atoms to which they are attached, are optionally joined to form a tricyclic fused ring;
• wherein at least two of the ring hydrogen atoms among A, B and D rings are substituted.