Devices and methods for detecting amniotic fluid in vaginal secretions
AssigneeN-Dia, Inc.
InventorsBoris Fuks, Dmitrii D. Petrunin, Evgeny I. Zaraisky, Marina N. Boltovskaya, Svetlana V. Nazimova, Nelly A. Starosvetskaya, Alexandr Konstantinov, Margarita I. Marshiskaia
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Abstract
The present invention relates to a diagnostic method for the detection of small quantities of amniotic fluid in the vagina. More specifically, the invention relates to the detection of PAMG-1 in the vagina using anti-PAMG-1 antibodies.
Claims17
A device comprising a detector section having a mobilizable antibody specific for PAMG-1 which is upstream from a capture section having an immobilized antibody specific for PAMG-1, wherein the capture section also comprises at least one other monoclonal anti-PAMG-1 antibody exhibiting lower binding specificity to PAMG-1 than the mobilizable and immobilizable PAMG-1 antibodies, intended to be used in combination with the mobilizable and immobilizable PAMG-1 antibodies, whereby mobilization of the mobilizable antibody by a fluid sample permits binding of the mobilizable antibody to any PAMG-1 in the sample, and binding of the mobilizable antibody-PAMG-1 complex formed thereby to the immobilized antibody, wherein the mobilizable antibody comprises a marker.
A device comprising a detector section having mobilizable antibody specific for PAMG-1, which is upstream from a capture section having an immobilized antibody specific for PAMG-1, wherein the mobilizable antibody is M271, produced by hybridoma N271, deposited with the Russian National Collection of Industrial Microorganisms (VKPM) Depository and assigned accession number VKPM-93, and wherein the immobilizable antibody is M52, produced by hybridoma N52, deposited with the VKPM and assigned accession number VKPM-92, wherein the mobilizable antibody comprises a marker.
Dependencies are inferred from the claim text.