Method for diagnosing a pervasive developmental disorder
OwnerMichael Chezinventor
Life of this patent
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Abstract
A method for diagnosing a pervasive developmental disorder, such as autism, comprising obtaining a sample of cerebrospinal fluid from a subject; obtaining a sample of serum from a subject; testing the cerebrospinal fluid of the subject for a concentration of TNF-α; testing the serum of the subject for a concentration of TNF-α; and positively diagnosing a pervasive developmental disorder when the concentration ratio of TNF-α in the cerebrospinal fluid of the subject to TNF-α in the serum of the subject exceeds approximately 2:1 over normal control concentrations.
Claims19
A method for diagnosing a pervasive developmental disorder, comprising:
- obtaining a sample of cerebrospinal fluid from a subject;
- obtaining a sample of serum from a subject;
- testing the cerebrospinal fluid of the subject for a concentration of TNF-α;
- testing the serum of the subject for a concentration of TNF-α;
- and
- positively diagnosing a pervasive developmental disorder when the concentration ratio of TNF-α in the cerebrospinal fluid of the subject to TNF-α in the serum of the subject exceeds 2:1 over normal control concentrations.
A method for diagnosing autism, comprising:
- obtaining a sample of cerebrospinal fluid from a child less than about 84 months old;
- obtaining a sample of serum from the child, wherein said obtaining samples of cerebrospinal fluid and serum from the child occur simultaneously;
- testing the cerebrospinal fluid of the child for a concentration of TNF-α;
- testing the serum of the child for a concentration of TNF-α;
- and
- positively diagnosing autism when the concentration ratio of TNF-α in the cerebrospinal fluid to TNF-α in the serum exceeds 2:1 over the concentration ratio of TNF-α in the cerebrospinal fluid of a subject to TNF-α in the serum of a child without autism.
A method for monitoring a therapy for pervasive developmental disorder, comprising:
- obtaining a sample of cerebrospinal fluid from a subject;
- obtaining a sample of serum from a subject;
- testing the cerebrospinal fluid of the subject for a concentration of TNF-α;
- testing the serum of the subject for a concentration of TNF-α;
- and
- monitoring the concentration ratio of TNF-α in the cerebrospinal fluid of the subject to TNF-α in the serum of the subject.
Dependencies are inferred from the claim text.