Methods of inhibiting unwanted cell proliferation using hedgehog antagonists
AssigneeCuris, Inc.
InventorsHenryk Dudek, Irina Karavanov, Carmen Pepicelli, Karen Kotkow, Lee L. Rubin
Life of this patent
Estimating the term…
Abstract
The present application is directed to compositions and methods for inhibiting angiogenesis and treating or preventing unwanted cell proliferation, including tumors, by inhibiting the hedgehog pathway, e.g., with an antagonist of the hedgehog pathway such as those disclosed herein.
Claims63
A method of treating a diseased or disordered tissue, comprising
- (a) determining whether said tissue overexpresses a gli-1 gene, and
- (b) contacting said tissue which overexpresses a gli-1 gene with an effective amount of a hedgehog antagonist, which hedgehog antagonist is a hedgehog antibody that binds to Sonic hedgehog protein and inhibits hedgehog signaling;
- wherein the diseased or disordered tissue is tissue exhibiting urogenital cancer, and
- wherein contacting said tissue with said hedgehog antagonist treats the diseased or disordered tissue.
A method of treating a diseased or disordered tissue, comprising
- (a) determining whether said tissue overexpresses a Sonic hedgehog gene, and
- (b) contacting said tissue which overexpresses said Sonic hedgehog gene with an effective amount of a hedgehog antagonist, which hedgehog antagonist is a hedgehog antibody that binds to Sonic hedgehog protein and inhibits hedgehog signaling;
- wherein the diseased or disordered tissue is tissue exhibiting urogenital cancer, and
- wherein contacting said tissue with said hedgehog antagonist treats the diseased or disordered tissue.
A method of treating a diseased or disordered tissue in a patient in need thereof, comprising
- (a) determining whether said tissue overexpresses a Sonic hedgehog gene, and
- (b) contacting said tissue which overexpresses said Sonic hedgehog gene with an effective amount of a hedgehog antibody that binds to Sonic hedgehog protein and antagonizes hedgehog signaling;
- wherein the diseased or disordered tissue is tissue exhibiting urogenital cancer, and
- wherein contacting said tissue with said hedgehog antibody decreases unwanted cell proliferation and treats said diseased or disordered tissue in said patient in need thereof.
A method of treating a diseased or disordered tissue, comprising
- (a) determining whether said tissue overexpresses a Sonic hedgehog gene, and
- (b) contacting said tissue which overexpresses said Sonic hedgehog gene with an effective amount of a hedgehog antibody that binds to Sonic hedgehog protein, which hedgehog antibody is 5E1 or an antibody which binds the same epitope as 5E1;
- wherein the diseased or disordered tissue is tissue exhibiting urogenital cancer, and
- wherein contacting said tissue with said hedgehog antibody decreases unwanted cell proliferation and treats said diseased or disordered tissue.
A method of treating a urogenital cancer in a patient in need thereof, comprising ascertaining whether cells in the cancer overexpress a Sonic hedgehog gene, and contacting diseased or disordered tissue of said patient exhibiting urogenital cancer with an effective amount of a hedgehog antibody that binds to Sonic hedgehog protein and inhibits hedgehog signaling, wherein the diseased or disordered tissue exhibiting urogenital cancer overexpresses a Sonic hedgehog gene.
A method of treating a urogenital cancer in a patient in need thereof, comprising ascertaining whether cells in the cancer overexpress a Sonic hedgehog gene, and administering to said patient in need thereof an amount of a hedgehog antagonist sufficient to decrease at least one of the growth or proliferation of urogenital cancer tissue, wherein the hedgehog antagonist is a hedgehog antibody that binds to Sonic hedgehog protein and inhibits hedgehog signaling, and wherein the urogenital cancer tissue overexpresses a Sonic hedgehog gene.
A method of treating a diseased or disordered tissue in a patient in need thereof, comprising ascertaining whether the diseased or disordered tissue overexpresses a gli-1 gene or a Sonic hedgehog gene, and administering to said patient in need thereof an amount of a hedgehog antagonist effective to decrease at least one of the growth or proliferation of the disease or disordered tissue;
- wherein the hedgehog antagonist is a hedgehog antibody that binds to Sonic hedgehog protein and inhibits hedgehog signaling;
- and wherein the diseased or disordered tissue is tissue exhibiting urogenital cancer and that overexpresses a gli-1 gene or a Sonic hedgehog gene.
Dependencies are inferred from the claim text.