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AssigneeEsperion Therapuetics, Inc.
InventorsCarmen Daniela Oniciu, Jean-Louis Henri Dasseux
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The present invention relates to novel ketone compounds, compositions comprising ketone compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising a ketone compound. The compounds, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's Disease, Syndrome X, peroxisome proliferator activated receptor-related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer, inflammation, and impotence. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.
A compound or pharmaceutically acceptable salt, hydrate, or solvate thereof selected from:
A method of increasing HDL levels, which comprises administering to a patient in need of such treatment a therapeutically effective amount of a compound pharmaceutically acceptable salt, hydrate, or solvate thereof selected from:
A method of decreasing LDL levels, which comprises administering to a patient in need of such treatment a therapeutically effective amount of a compound pharmaceutically acceptable salt, hydrate, or solvate thereof selected from:
Dependencies are inferred from the claim text.