Foamable vehicle and pharmaceutical compositions thereof
AssigneeFoamix Ltd.
InventorsDov Tamarkin, Doron Friedman, Meir Eini, Alex Besonov
Life of this patent
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Abstract
A hygroscopic pharmaceutical composition includes at least one hygroscopic substance at a concentration sufficient to provide an Aw value of at least 0.9 and an antiinfective agent. A foamble pharmaceutical carrier includes about 50% to about 98% of a polar solvent selected from the group consisting of a polyol and PEG; 0% to about 48% of a secondary polar solvent; about 0.2% to about 5% by weight of a surface-active agent; about 0.01% to about 5% by weight of at least one polymeric agent; and a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition.
Claims75
A hygroscopic pharmaceutical composition in a pressurized container comprising:
- a. at least one hygroscopic substance at a sufficient concentration to provide an Aw value of the hygroscopic pharmaceutical composition of less than 0.9, wherein the hygroscopic substance comprises a polyethylene glycol (PEG) or a polyol;
- b. an anti-infective agent;
- c. about 0.01% to about 5% by weight of at least one polymeric agent, wherein the polymeric agent is a gelling agent;
- d. about 0.2% to about 5% by weight of a surface-active agent;
- and
- e. a liquefied or compressed gas propellant;
- wherein the composition comprises not more than 10% or about 10% water by weight;
- and
- wherein the composition forms a breakable foam upon dispensing from the pressurized container.
A foamable pharmaceutical carrier in a pressurized container comprising:
- a. about 50% to about 98% of a polar solvent selected from the group consisting of (1) a polyol and (2) a polyethylene glycol (PEG);
- b. 0% to about 48% of a secondary polar solvent;
- c. about 0.2% to about 5% by weight of a surface-active agent;
- d. about 0.01% to about 5% by weight of at least one polymeric agent selected from a bioadhesive agent, a gelling agent, a film forming agent and a phase change agent;
- and
- e. a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition;
- wherein the carrier comprises not more than 10% or about 10% water by weight and wherein the carrier forms a breakable foam upon dispensing from the pressurized container.
A foamable therapeutic composition in a pressurized container comprising:
- a. a therapeutically effective concentration of an active agent;
- b. about 50% to about 98% of a polar solvent selected from the group consisting of(1) a polyol;
- and (2) a polyethylene glycol;
- c. 0% to about 48% of a secondary polar solvent;
- d. about 0.2% to about 5% by weight of a surface-active agent;
- e. about 0.01% to about 5% by weight of at least one polymeric agent selected from a bioadhesive agent, a gelling agent, a film forming agent and a phase change agent;
- and
- f. a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition.
- wherein the composition comprises not more than 10% or about 10% water by weight and
- wherein, the composition forms a breakable foam upon dispensing from the pressurized container.
A method of treating a disorder of mammalian subject, comprising:
- administering a foamable therapeutic composition to a target site, the composition comprising:
- a. a therapeutically effective concentration of an active agent;
- b. about 50% to about 98% of a polar solvent selected from the group consisting of(1) a polyol;
- and (2) a polyethylene glycol;
- c. 0% to about 48% of a secondary polar solvent;
- d. about 0.2% to about 5% by weight of a surface-active agent;
- e. about 0.01% to about 5% by weight of at least one polymeric agent selected from a bioadhesive agent, a gelling agent, a film forming agent and a phase change agent;
- and
- f. a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition;
- wherein the composition comprises not more than 10% or about 10% water by weight;
- and
- wherein the composition forms a breakable foam upon dispensing from a pressurized container.
Dependencies are inferred from the claim text.