# US 7,704,513 B2 · Nucleic acids and polypeptides specific for pathogenic strains of the Neisseria genus

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- Number: US 7,704,513 B2
- Document ID: US7704513B2
- Status: Granted
- Kind: B2
- Application number: 12/056,911
- Filed: 2008-03-27
- Published: 2009-06-18
- Granted: 2010-04-27
- Earliest claimed: 1998-10-30
- Assignees: Aventis Pasteur Limited; Institut National De La Sante Et De La Recherche Medicale (Inserm)
- Inventors: Luc Aujame; Annabelle Bouchardon; Geneviève Renauld-Mongenie; Bachra Rokbi; Xavier Nassif; Colin Tinsley; Agnès Perrin
- Web page: https://patentgrep.com/patent/US7704513B2

## CPC

- A61K 39/095: Neisseria
- C07K 14/22: from Neisseriaceae (F)
- C07K 16/1217: Neisseriaceae (F)
- A61K 39/00: Medicinal preparations containing antigens or antibodies (materials for immunoassay G01N33/53)
- A61K 2039/51: {comprising whole cells, viruses or DNA/RNA}
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)

## Abstract

The invention concerns nucleic acids coding for polypeptides specific of the Neisseria genus pathogenic strains, the corresponding polypeptides, and their diagnostic and therapeutic applications.

## Claims

### Claim 1

An isolated nucleic acid which encodes the amino acid sequence as shown in SEQ ID NO: 50.

### Claim 2 (depends on 1)

The isolated nucleic acid according to claim 1, which has the sequence SEQ ID NO: 49.

### Claim 3 (depends on 1)

An isolated expression vector comprising an expression cassette in which a nucleotide sequence as defined in claim 1 is placed under conditions allowing expression of said nucleotide sequence in a host cell.

### Claim 4 (depends on 3)

A host cell transformed with the expression vector according to claim 3.

### Claim 5 (depends on 2)

An isolated nucleic acid expression vector comprising an expression cassette in which a nucleotide sequence as defined in claim 2 is placed under conditions allowing expression of said nucleotide sequence in a host cell.

### Claim 6 (depends on 5)

A host cell transformed with the expression vector according to claim 5.